In January 2005, ZyCare completed formal clinical trials of its CoagCare ® system at 3 locations with 100 patients. The study was supported by an SBIR grant to ZyCare from the NHLBI as well as by the International Technidyne Corporation.

ZyCare has developed an innovative approach utilizing expert systems and the Internet to automate much of the routine decision making involved in remotely managing patients with chronic conditions. ZyCare's systems directly involve the patient in gathering information that drives automated treatment recommendations, while giving physicians a vehicle to closely monitor their patients' progress without random and time-consuming telephone calls and faxes. This approach allows the healthcare system to cost-effectively take advantage of the new home monitoring devices that are being developed and marketed for chronic conditions. The Company believes that its approach gives patients more control over their own condition, and allows medical personnel to focus on those patients needing their attention. ZyCare has chosen to introduce its system approach by addressing a very specific area, the facilitation of physician-supervised patient self-testing (PST) of oral anticoagulation therapy with warfarin (Coumadin®). While warfarin therapy is relatively inexpensive and well tolerated, its potency as an anticoagulant depends up what foods and medications a patient is using. Therefore, it is not easy for the physician to get the dosage just right. If a patient is too anticoagulated he can suffer from dangerous bleeding, while too little anticoagulation can leave the patient at risk for blood clots and strokes. Consequently, most patients on warfarin must visit their doctor once or twice a month to have their blood tested and their warfarin dosages adjusted. Frequent communication between visits is often required. This is inconvenient for the patients, and very costly for the managing physicians. To solve this problem, ZyCare has created the CoagCare system. CoagCare is an Internet-enabled expert system. Both patients and healthcare providers can access the system through a browser from any location.

While the Coagcare grant is their most recent, ZyCare has a long history with the SBIR program. Having been started in the 80's ZyCare was one of the first companies to receive an SBIR grant. Since then they have received a number of SBIR grants from different branches of the NIH. Thy have found the SBIR program to be especially helpful as a proof of concept which opens up corporate sponsorship and partnerships. Specifically ZyCare has been able to take advantage of the SBIR FastTrack program which promises a phase II grant if all of the Phase I benchmarks are met. This has allowed them to reach the commercialization of a product much faster than having to re-apply. Currently ZyCare's main goal is to streamline the process of patient-doctor interaction.